Comparison of cognitive deficits among drug-naive patients with schizophrenia and major depressive disorder.

摘要: Abstract Background Cognitive deficits have been well-established among patients with severe mental illness. The aim of this study was to clarify the patterns cognitive in drug-naive schizophrenia and non-psychotic major depressive disorder (MDD) as compared controls. Methods Thirty participants schizophrenia, 30 counterparts MDD, age-, sex-, education years-matched healthy controls were recruited. Neuropsychological tests, including Wisconsin Card Test (WCST), Continuous Performance (CPT) Finger Tapping (FTT), administered. Results Patients performed more poorly than MDD normal WCST. both CPT. also FTT. Limitations age onset younger previous reports. cross-sectional design, small sample sizes, limited numbers neuropsychological domains are all obstacles making a clear causal conclusion. Conclusions These results revealed distinct pattern neurocognitive dysfunction which may imply different underlying neurobiological mechanisms MDD.