A Comparison of Neuropsychological Dysfunction in First-Episode Psychosis Patients with Unipolar Depression, Bipolar Disorder, and Schizophrenia

摘要: The severity and profile of cognitive dysfunction in first episode schizophrenia psychotic affective disorders were compared before after antipsychotic treatment. Parallel recruitment consecutively admitted study-eligible first-episode patients (30 schizophrenia, 22 bipolar with psychosis, 21 depression) reduced confounds acute chronic disease/medication effects as well differential treatment course. Patient groups completed a neuropsychological battery demographically similar to healthy controls (n=41) studied parallel. Prior treatment, displayed significant deficits all domains. two also impaired overall, generally performing intermediate between the comparison groups. No differences observed across patient Following 6 weeks no group improved more than practice seen individuals, level performance improvement was for psychosis Although less severe disorders, profiles generalized Recovery function clinical stabilization mood schizophrenia. To extent that these findings are generalizable, like may be trait-like persistent functional implications.