Mechanism of DNA fragmentation during hypoxia in the cerebral cortex of newborn piglets.
作者： Ming-Chou Chiang , Qazi M. Ashraf , Om P. Mishra , Maria Delivoria-Papadopoulos
DOI: 10.1007/S11064-007-9574-8
关键词: Molecular biology 、 DNA fragmentation 、 Caspase 、 Hypoxia (medical) 、 Apoptosis 、 Caspase-activated DNase 、 Biology 、 Nuclear DNA 、 Cerebral cortex 、 Nucleus
摘要: We have previously shown that hypoxia results in increased activity of caspase-9, caspase-3 and fragmentation nuclear DNA the cerebral cortex newborn piglets. The present study tested hypothesis mechanism during piglets is mediated by caspase-9-dependent activation. Newborn were randomly assigned to normoxic, hypoxic, hypoxic pretreated with a highly selective caspase-9 inhibitor, Z-LEHD-FMK groups. data showed tissue expression caspase-activated DNase (CAD) protein nucleus DNA. A pretreatment attenuated CAD Based on these results, we conclude which was fragmented activation consequence
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