Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome.

作者: Felipe Henriques , Magno A Lopes , Felipe O Franco , Pamela Knobl , Kaltinaitis B Santos

DOI: 10.1038/S41598-018-36626-3

关键词: TLR4MedicineCachexiaSystemic inflammationLewis lung carcinomaToll-like receptorAdipocyteAdipose tissueCancer researchAtrophy

摘要: … life, decreased survival, and increased complications due to cancer treatment. Cachexia is the main cause of death in approximately 20% to 30% of all patients with cancer 2 . In cancer …

参考文章(49)
Miguel L Batista Jr, Felipe S Henriques, Rodrigo X Neves, Mireia R Olivan, Emídio M Matos‐Neto, Paulo SM Alcântara, Linda F Maximiano, José P Otoch, Michele J Alves, Marília Seelaender, None, Cachexia-associated adipose tissue morphological rearrangement in gastrointestinal cancer patients. Journal of Cachexia, Sarcopenia and Muscle. ,vol. 7, pp. 37- 47 ,(2016) , 10.1002/JCSM.12037
A. Iwata, R. Shirai, H. Ishii, H. Kushima, S. Otani, K. Hashinaga, K. Umeki, K. Kishi, I. Tokimatsu, K. Hiramatsu, J. Kadota, Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells. Clinical and Experimental Immunology. ,vol. 168, pp. 234- 240 ,(2012) , 10.1111/J.1365-2249.2012.04564.X
Praveen Chansrichavala, Udom Chantharaksri, Piyamitr Sritara, Sansanee C. Chaiyaroj, Atorvastatin attenuates TLR4-mediated NF-kappaB activation in a MyD88-dependent pathway. Asian Pacific Journal of Allergy and Immunology. ,vol. 27, pp. 49- 57 ,(2009)
Serkan Kir, James P. White, Sandra Kleiner, Lawrence Kazak, Paul Cohen, Vickie E. Baracos, Bruce M. Spiegelman, Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia Nature. ,vol. 513, pp. 100- 104 ,(2014) , 10.1038/NATURE13528
Kenneth Fearon, Jann Arends, Vickie Baracos, Understanding the mechanisms and treatment options in cancer cachexia Nature Reviews Clinical Oncology. ,vol. 10, pp. 90- 99 ,(2013) , 10.1038/NRCLINONC.2012.209
Bruce A. Beutler, TLRs and innate immunity. Blood. ,vol. 113, pp. 1399- 1407 ,(2009) , 10.1182/BLOOD-2008-07-019307
Matthew T. Campbell, Karen L. Hile, Hongji Zhang, Hiroshi Asanuma, Brian A. Vanderbrink, Richard R. Rink, Kirstan K. Meldrum, Toll-like receptor 4: A novel signaling pathway during renal fibrogenesis Journal of Surgical Research. ,vol. 168, ,(2011) , 10.1016/J.JSS.2009.09.053
Osamu Takeuchi, Hideki Sanjo, Katsuaki Hoshino, Yoshifumi Takeda, Kiyoshi Takeda, Shizuo Akira, Tomohiko Ogawa, Taro Kawai, Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. Journal of Immunology. ,vol. 162, pp. 3749- 3752 ,(1999)
Praveen Chansrichavala, Udom Chantharaksri, Piyamitr Sritara, Nathamon Ngaosuwankul, Sansanee C. Chaiyaroj, Atorvastatin affects TLR4 clustering via lipid raft modulation International Immunopharmacology. ,vol. 10, pp. 892- 899 ,(2010) , 10.1016/J.INTIMP.2010.04.027
Maurizio Bossola, Maurizio Muscaritoli, Paola Costelli, Gabriella Grieco, Gabriella Bonelli, Fabio Pacelli, Filippo Rossi Fanelli, Giovanni Battista Doglietto, Francesco Maria Baccino, Increased Muscle Proteasome Activity Correlates With Disease Severity in Gastric Cancer Patients Annals of Surgery. ,vol. 237, pp. 384- 389 ,(2003) , 10.1097/01.SLA.0000055225.96357.71