Concise total synthesis of botryolide B
作者： Debendra K. Mohapatra , Gonela Umamaheshwar , M. Mallikarjuna Rao , Deivasigamani Umadevi , Jhillu S. Yadav
DOI: 10.1039/C3RA44478C
关键词: Botryolide B 、 Ring (chemistry) 、 Fragment (computer graphics) 、 Total synthesis 、 Ring-closing metathesis 、 Alcohol 、 Yield (chemistry) 、 Carboxylic acid 、 Stereochemistry 、 Chemistry
摘要: An efficient total synthesis of botryolide B was achieved in 9 longest linear steps with 22% overall yield via esterification a carboxylic acid an alcohol fragment and ring closing metathesis (RCM) reaction as pivotal to construct the macrolactone system. Our novel approach for 2-alkene-1,5-diol by followed reductive opening strategy, whereas accessed from commercially available (R)-(+)-α-hydroxy-γ-butyrolactone three steps.
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