Synthesis and Biological Investigation of Δ(12)-Prostaglandin J3 (Δ(12)-PGJ3) Analogues and Related Compounds.
作者： K. C. Nicolaou , Kiran Kumar Pulukuri , Stephan Rigol , Philipp Heretsch , Ruocheng Yu
DOI: 10.1021/JACS.6B02075
关键词:
摘要: A series of Δ(12)-prostaglandin J3 (Δ(12)-PGJ3) analogues and derivatives were synthesized employing an array synthetic strategies developed specifically to render them readily available for biological investigations. The compounds evaluated their cytotoxicity against a number cancer cell lines, revealing nanomolar potencies certain lines. Four (2, 11, 21, 27) demonstrated inhibition nuclear export through covalent addition at Cys528 the receptor Crm1. One these (i.e., 11) is currently under evaluation as potential drug candidate treatment types cancer. These studies culminated in useful path-pointing structure-activity relationships (SARs) that provide guidance further improvements biological/pharmacological profiles within this class.
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