Multiplex methylation-specific amplification systems and methods

作者: Edward Granados

DOI:

关键词: Molecular biologyBiologyMultiplexMethylationComputational biology

摘要: The present invention relates to systems and methods for performing multiplex amplification reactions. In particular, the methylation-specific methods.

参考文章(117)
Alberto M. Marchevsky, Jeffrey A. Tsou, Ite A. Laird-Offringa, Classification of Individual Lung Cancer Cell Lines Based on DNA Methylation Markers The Journal of Molecular Diagnostics. ,vol. 6, pp. 28- 36 ,(2004) , 10.1016/S1525-1578(10)60488-6
Larry J. Kricka, Nonisotopic probing, blotting, and sequencing Academic Press. ,(1995)
Thomas G. Laffler, Edward N. Granados, Determination of methylation status of polynucleotides ,(2010)
Katsutoshi Takahashi, Ryoichi Asai, Ali Arjomand, Nucleic acid methylation detection process using an internal reference sample ,(2003)
Shiao-Chun Tu, James Briggs, Xiaolian Gao, Richard Willson, Susan Hardin, Methods for real-time single molecule sequence determination ,(2004)
Shoji Nakata, Kenji Sugio, Hidetaka Uramoto, Tsunehiro Oyama, Takeshi Hanagiri, Masaru Morita, Kosei Yasumoto, The methylation status and protein expression of CDH1, p16INK4A, and fragile histidine triad in nonsmall cell lung carcinoma Cancer. ,vol. 106, pp. 2190- 2199 ,(2006) , 10.1002/CNCR.21870
Guido Hennig, Oliver Löwrick, Walter Birchmeier, Jürgen Behrens, Mechanisms Identified in the Transcriptional Control of Epithelial Gene Expression Journal of Biological Chemistry. ,vol. 271, pp. 595- 602 ,(1996) , 10.1074/JBC.271.1.595
Kary B. Mullis, Fred A. Faloona, Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods in Enzymology. ,vol. 155, pp. 335- 350 ,(1987) , 10.1016/0076-6879(87)55023-6
Daniel MacLean, Jonathan D. G. Jones, David J. Studholme, Application of 'next-generation' sequencing technologies to microbial genetics Nature Reviews Microbiology. ,vol. 7, pp. 96- 97 ,(2009) , 10.1038/NRMICRO2088