A novel, portable eye tracking system for use in schizophrenia research

作者: Barry R Greene , Stephen Meredith , Richard B Reilly , Gary Donohoe

DOI: 10.1049/CP:20040523

关键词: PsychologyCognitionMean valueSaccadeControl subjectsEndophenotypeAudiologyEye tracking systemSchizophrenia researchStimulus (physiology)

摘要: This paper outlines a methodology to measure the ability of schizophrenic patient saccade against presented stimulus by tracking patient's electro- oculographic (EOG) activity. The overall goal is investigate deficit in this anti-saccade task as cognitive endophenotype for schizophrenia. A portable system performing test and novel biopotential amplifier are along with signal processing method analysis. Results based on control subjects indicate that mean performance above 89% achievable. study 5 patients indicates drops value 45%. be carried out Trinity College Neuropsychiatric Genetics Research Group currently assessing up 800 including schizophrenics their relatives.

参考文章(10)
Michael F Marmor, Eberhart Zrenner, Standard for Clinical Electro-oculography Archives of Ophthalmology. ,vol. 111, pp. 601- 604 ,(1993) , 10.1001/ARCHOPHT.1993.01090050035023
JENNIFER E. McDOWELL, MARINA MYLES-WORSLEY, HILARY COON, WILLIAM BYERLEY, BRETT A. CLEMENTZ, Measuring liability for schizophrenia using optimized antisaccade stimulus parameters Psychophysiology. ,vol. 36, pp. 138- 141 ,(1999) , 10.1017/S0048577299980836
Jennifer E McDowell, Gregory G Brown, Martin Paulus, Antigona Martinez, Sara E Stewart, David J Dubowitz, David L Braff, Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects. Biological Psychiatry. ,vol. 51, pp. 216- 223 ,(2002) , 10.1016/S0006-3223(01)01204-5
A. Hochrein, N. Kathmann, E. Meisenzahl, P477 Saccadic eye movements in patients with schizophrenic disorders Electroencephalography and Clinical Neurophysiology. ,vol. 99, pp. 384- ,(1996) , 10.1016/0013-4694(96)88652-4
J.J. Gu, Max Meng, A. Cook, M.G. Faulkner, A study of natural eye movement detection and ocular implant movement control using processed EOG signals international conference on robotics and automation. ,vol. 2, pp. 1555- 1560 ,(2001) , 10.1109/ROBOT.2001.932832
Ulrich Ettinger, Veena Kumari, Trevor J. Crawford, Philip J. Corr, Mrigendra Das, Elizabeth Zachariah, Catherine Hughes, Alex L. Sumich, Sophia Rabe-Hesketh, Tonmoy Sharma, Smooth pursuit and antisaccade eye movements in siblings discordant for schizophrenia Journal of Psychiatric Research. ,vol. 38, pp. 177- 184 ,(2004) , 10.1016/S0022-3956(03)00105-5
Monica E. Calkins, William G. Iacono, Clayton E. Curtis, Smooth pursuit and antisaccade performance evidence trait stability in schizophrenia patients and their relatives International Journal of Psychophysiology. ,vol. 49, pp. 139- 146 ,(2003) , 10.1016/S0167-8760(03)00101-6
Jennifer E. McDowell, Colleen A. Brenner, Marina Myles-Worsley, Hilary Coon, William Byerley, Brett A. Clementz, Ocular motor delayed-response task performance among patients with schizophrenia and their biological relatives Psychophysiology. ,vol. 38, pp. 153- 156 ,(2001) , 10.1111/1469-8986.3810153
M.S. Panse, S.K. Kulkarni, Application of digital signal processing in ophthalmic research: a new horizon in biomedical engineering engineering in medicine and biology society conference. ,(1995) , 10.1109/RCEMBS.1995.532171
Rangaraj M. Rangayyan, Biomedical Signal Analysis ,(2001)