作者: Barry R Greene , Stephen Meredith , Richard B Reilly , Gary Donohoe
DOI: 10.1049/CP:20040523
关键词: Psychology 、 Cognition 、 Mean value 、 Saccade 、 Control subjects 、 Endophenotype 、 Audiology 、 Eye tracking system 、 Schizophrenia research 、 Stimulus (physiology)
摘要: This paper outlines a methodology to measure the ability of schizophrenic patient saccade against presented stimulus by tracking patient's electro- oculographic (EOG) activity. The overall goal is investigate deficit in this anti-saccade task as cognitive endophenotype for schizophrenia. A portable system performing test and novel biopotential amplifier are along with signal processing method analysis. Results based on control subjects indicate that mean performance above 89% achievable. study 5 patients indicates drops value 45%. be carried out Trinity College Neuropsychiatric Genetics Research Group currently assessing up 800 including schizophrenics their relatives.