Metal-Free Synthesis of Fully Substituted Pyridines via Ring Construction Based on the Domino Reactions of Enaminones and Aldehydes
作者： Jie-Ping Wan , Yanfeng Jing , Changfeng Hu , Shouri Sheng
关键词: Domino 、 Chemistry 、 Cascade reaction 、 Organic chemistry 、 Ring (chemistry) 、 Primary (chemistry) 、 Combinatorial chemistry 、 Metal free
摘要: An unprecedented domino reaction involving primary enaminones/enaminoesters and aldehydes has been developed for the synthesis of fully substituted pyridines. The construction products accomplished via cascade generation two C–C one C–N bond by simply using TfOH as a promoter.
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