Epithelial cell transformation sequence 2 is a potential biomarker of unfavorable survival in human gliomas

摘要: Background: High-grade primary gliomas are invasive and have poor outcome. The identification of biomarkers predictive outcome in patients with is crucial for clinical follow-up. Epithelial cell transformation sequence 2 (ECT2) modulates cancer invasion, progression, metastasis cycle regulation. However, its role determining the human warrants further elucidation. Materials Methods: This study hypothesized that ECT2 over-expressed gliomas. We analysis de-linked data (GDS1815/219787_s_at/ECT2) high-grade glioma, exclude 23 sheets without detailed information. An additional database (GDS1962/234992_x_at/ECT2) was also included to evaluation gene expression each pathologic grading. Results: Analysis Gene Expression Omnibus (GEO) profile showed mRNA level higher WHO grade IV (n = 81) than II 7, P 0.0126) non-tumor controls 23; 1.65 Χ 10 -8 ). Kaplan-Meier unfavorable survival high levels 10) those low 67) (median survival, 106 vs. 46 weeks, < 0.0001, by log-rank test, Hazard ratio: 0.07850, 95% CI: 0.02402-0.2565). Conclusions: positively correlated grading suggesting may be a potential therapeutic candidate