THYROTOXICOSIS AND THE HEART

摘要: Cardiovascular signs and symptoms contribute in an important manner to the manifestations of thyrotoxicosis. This was first recognized over 200 years ago by British physician Caleb Parry also noticed description hyperthyroidism Graves Basedow (1,2). Patients with are usually well aware their cardiovascular symptoms. They frequently complain a strong pounding heartbeat increased heart rate. These features accompanied increasing shortness breath vigorous exercise. The precise pathophysiological mechanisms which underlie still, part, unclear. I will review clinical hyperthyroid disease subsequently briefly discuss basis manifestations. In addition, more recent insights developed from transgenic knockout mouse models different isoforms thyroid hormone receptors overexpressed or underexpressed be considered. Some these findings providing novel into molecular action system can explain detail hyperthyroidism.