Pathology of the thyroid in amiodarone-associated thyrotoxicosis

摘要: Among 83 consecutive patients operated on for thyrotoxicosis at the Mayo Clinic between January 1, 1980 and May 1986, four had a combination of pathologic findings that were similar unexpected: involutional changes; degenerative destructive follicular lesions; zones fibrosis. These four, but none remaining 79, being treated with amiodarone cardiac tachyarrhythmias; this drug is known to be taken up by thyroid gland. Characteristically, small groups involuted follicles exhibited varying degrees damage ranging from changes in few lining cells total destruction. Damaged swollen featured granular or vacuolated cytoplasm. This type cytoplasmic alteration has been reported occur pneumocytes hepatocytes damaged amiodarone. Therefore, probably cause cell damage, disruption (with consequent release iodothyronines into circulation) likely an important contributor associated thyrotoxicosis.