摘要: Amiodarone is a potent antiarrhythmic drug associated with thyroid dysfunction. Its high iodine content causes inhibition of 5'-deiodinase activity. Most patients remain euthyroid. Amiodarone-induced thyrotoxicosis (AIT) or amiodarone-induced hypothyroidism (AIH) may occur depending on the status individuals and prior disease. AIT caused by excess iodine-induced hormone synthesis (type I AIT) destructive thyroiditis II AIT). If medical condition allows it, discontinuation recommended in type AIT. Otherwise, large doses thioamides are required. Type treated corticosteroids. Mixed cases require combination both drugs. Potassium perchlorate has been used to treat resistant but use limited toxicity. Thyroidectomy, plasmapheresis, lithium, radioiodine select AIH successfully levothyroxine. Screening for disease before starting amiodarone periodic monitoring function tests advocated.
sci-hub.se 参考文章(82)
David C. Mulligan, Christopher R. McHenry, William Kinney, Caldwell B. Esselstyn, Amiodarone-induced thyrotoxicosis: clinical presentation and expanded indications for thyroidectomy. Surgery. ,vol. 114, pp. 1114- 1119 ,(1993) , 10.5555/URI:PII:0039606093903317
S.L. Rabinowe, P.R. Larsen, E.M. Antman, K.L. George, P.L. Friedman, R.A. Jackson, G.S. Eisenbarth, Amiodarone therapy and autoimmune thyroid disease: Increase in a new monoclonal antibody-defined T cell subset The American Journal of Medicine. ,vol. 81, pp. 53- 57 ,(1986) , 10.1016/0002-9343(86)90181-6
Fausto Bogazzi, Luigi Bartalena, Maurizio Gasperi, Lewis E. Braverman, Enio Martino, The various effects of amiodarone on thyroid function. Thyroid. ,vol. 11, pp. 511- 519 ,(2001) , 10.1089/105072501300176471
M P J Vanderpump, J A O Ahlquist, J A Franklyn, R N Clayton, Consensus statement for good practice and audit measures in the management of hypothyroidism and hyperthyroidism BMJ. ,vol. 313, pp. 539- 544 ,(1996) , 10.1136/BMJ.313.7056.539
Aldo Pinchera, Lewis E. Braverman, Francesco Lippi, Lidio Baschieri, Fabrizio Aghini-Lombardi, Enio Martino, Marjorie Safran, Twenty-Four Hour Radioactive Iodine Uptake in 35 Patients with Amiodarone Associated Thyrotoxicosis The Journal of Nuclear Medicine. ,vol. 26, pp. 1402- 1407 ,(1985)
William J. McKenna, Louise Harris, Edward Rowland, Gerald Storey, David Holt, Amiodarone therapy during pregnancy American Journal of Cardiology. ,vol. 51, pp. 1231- 1233 ,(1983) , 10.1016/0002-9149(83)90377-6
Shehzad Basaria, David S. Cooper, Amiodarone and the thyroid The American Journal of Medicine. ,vol. 118, pp. 706- 714 ,(2005) , 10.1016/J.AMJMED.2004.11.028
M. Safran, E. Martino, F. Aghini-Lombardi, L. Bartalena, S. Balzano, A. Pinchera, L. E. Braverman, Effect of amiodarone on circulating antithyroid antibodies BMJ. ,vol. 297, pp. 456- 457 ,(1988) , 10.1136/BMJ.297.6646.456
Gillian C. Hawthorne, Amiodarone-Induced Hypothyroidism Archives of Internal Medicine. ,vol. 145, pp. 1016- 1019 ,(1985) , 10.1001/ARCHINTE.1985.00360060072009
Thomas C. Smyrk, John R. Goellner, Michael D. Brennan, J Aidan Carney, Pathology of the thyroid in amiodarone-associated thyrotoxicosis The American Journal of Surgical Pathology. ,vol. 11, pp. 197- 204 ,(1987) , 10.1097/00000478-198703000-00004