Amiodarone-Induced Hypothyroidism

摘要: • Amiodarone is a widely used antiarrhythmic drug, which contains 75 mg of iodide per 200 active substance. Eight our patients receiving long-term amiodarone therapy became hypothyroid. Seven these had no previous history thyroid dysfunction or goiter. Antithyroid antibodies were absent, and standard perchlorate discharge tests positive in seven when hypothyroidism was diagnosed. In one patient, withdrawn; over the next nine months, resolved, results test reverted to normal. We conclude that amiodarone-induced similar previously described iodide-induced hypothyroidism. It may develop absence disease, all should therefore be regularly monitored for (Arch Intern Med1985;145:1016-1019)