The temporary nature of the inhibitory action of excess iodine on organic iodine synthesis in the normal thyroid.

摘要: In 1944, Morton et al. observed that when 300 mg. of sheep thyroid slices were incubated in 3 cc. a bicarbonate-Ringer medium to which various amounts I127 as inorganic iodide had been added, inhibition thyroxine and diiodotryosine formation occurred the added exceeded 20 gamma. The resemblance this vitro effect action excess Graves’ disease man led us investigate phenomenon normal intact (Wolff Chaikoff, 1948a). addition confirming inhibitory upon synthesis thyroids, investigation showed such by single injection was related level plasma iodine 1948b). So long concentration 20–35 gamma per cent, organic binding failed occur gland,