Introduction to Therapeutic Drug Monitoring. Frequently and Less Frequently Monitored Drugs

摘要: Therapeutic drug monitoring is useful for individual dosage adjustment and avoiding toxicity certain drugs with a narrow therapeutic window. However, only relatively few require most of these are used treating chronic condition. The exceptions vancomycin aminoglycosides, which short time life-threatening infection. These due to their high threshold toxicity. In general approximately 26 routinely monitored in clinical laboratories, there readily available immunoassays can be adopted on automated analyzers. include cardioactive drugs, anticonvulsants, anti-asthmatics, tricyclic antidepressants, immunosuppressants, antibiotics anticancer – commonly, methotrexate. There 25–30 that less frequently, not commercially available. Therefore, chromatographic methods usually employed determination serum, plasma or whole blood. newer anticonvulsants (such as lamotrigine gabapentin), (for example, flecainide, tocainide, etc.), several antidepressants the SSRI (selective serotonin reuptake inhibitor) class fluoxetine, paroxetine, sertraline).