Recent advances in iron homeostasis and regulation - a focus on epigenetic regulation and stroke.

摘要: Iron is an element with redox properties. It active sites of many enzymes and plays important role in various cellular biological functions including ATP production DNA synthesis. However, as a element, iron promotes free radical generation lipid peroxidation, causing oxidative damage cell death. Iron-mediated oxidation central player ferroptosis, type death process that different from apoptosis necrosis. Thus, metabolism homeostasis are sophisticatedly regulated. There has been exciting progress understanding regulation since hepcidin was recognized the regulator homeostasis. Hepcidin mainly regulates export function ferrous permease, ferroportin, which only known exporter expressed by mammalian cells. Particularly, epigenetic recent focus on Epigenetic phenomena have demonstrated to modulate key proteins metabolism. Here, we review rapid years molecular mechanisms hepcidin, ferritin, ferroptosis. Interactions between methionine also discussed. Furthermore, studies suggested severity neuronal after stroke proportional magnitude brain accumulation. Recent discoveries regarding briefly Understanding underlying mechanism could provide insight into treatment intractable diseases stroke.