The iron-regulatory hormone hepcidin: a possible therapeutic target?

摘要: The maintenance of stable extracellular and intracellular iron concentrations requires the coordinated regulation transport into plasma. Iron is a fundamental cofactor for several enzymes involved in oxidation-reduction reactions. redox ability can lead to production oxygen free radicals, which damage various cellular components. Therefore, appropriate systemic homeostasis decisive vital processes. Hepcidin has emerged as central regulatory molecule homeostasis. It synthesized hepatocytes other cells released circulation. inhibits release from enterocytes duodenum macrophages by binding exporter protein, ferroportin (FPN). FPN transmembrane protein responsible export internalized with both are degraded lysosomes. hepcidin-FPN axis principal regulator health disease. Its manipulation via agonists antagonists an attractive novel therapeutic strategy. include compounds that mimic activity hepcidin agents increase targeting hepcidin-regulatory molecules. inhibition could be potentially strategy patients suffering anaemia or chronic inflammation. In this review, we will summarize role its contribution pathophysiology inflammation disorders. We examine emerging new strategies modulate metabolism.