Expression of the peptide hormone hepcidin increases in cardiomyocytes under myocarditis and myocardial infarction
作者： Manabu Isoda , Haruo Hanawa , Ritsuo Watanabe , Tsuyoshi Yoshida , Ken Toba
DOI: 10.1016/J.JNUTBIO.2009.04.009
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摘要: Abstract The micronutrient iron is an essential component that plays a role in many crucial metabolic reactions. peptide hormone hepcidin thought to play central homeostasis and its expression induced by overloading inflammation. Recently, has been reported be expressed also the heart; however, kinetics of altered diseases heart remain unknown. In this study, we examined cardiac rat experimental autoimmune myocarditis (EAM), human acute myocardial infarction (AMI). EAM AMI hearts, was cardiomyocytes; ferroportin, which cellular exporter bound hepcidin, various cells. Analysis time course cytochrome oxidase subunit 6a (Cox6a)2 ratio showed it abruptly increased more than 100-fold hearts very early phase infarcted areas 1 day after MI. hepcidin/Cox6a2 correlated significantly with interleukin-6/γ-actin both (r=0.781, P
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A. Schlerf, M. Droste, M. Winter, B. Kadenbach, Characterization of two different genes (cDNA) for cytochrome c oxidase subunit VIa from heart and liver of the rat. The EMBO Journal. ,vol. 7, pp. 2387- 2391 ,(1988) , 10.1002/J.1460-2075.1988.TB03083.X
W. J. Parsons, R. S. Williams, J. M. Shelton, Y. Luo, D. J. Kessler, J. A. Richardson, Developmental regulation of cytochrome oxidase subunit VIa isoforms in cardiac and skeletal muscle. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 270, ,(1996) , 10.1152/AJPHEART.1996.270.2.H567
Yamauchi-Takihara, Kishimoto, Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance. International Journal of Experimental Pathology. ,vol. 81, pp. 1- 16 ,(2001) , 10.1046/J.1365-2613.2000.00139.X
Adriana Donovan, Alison Brownlie, YI Zhou, Jennifer Shepard, Stephen J Pratt, John Moynihan, Barry H Paw, Anna Drejer, Bruce Barut, Agustin Zapata, Terence C Law, Carlo Brugnara, Samuel E Lux, Geraldine S Pinkus, Jack L Pinkus, Paul D Kingsley, James Palis, Mark D Fleming, Nancy C Andrews, Leonard I Zon, None, Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter Nature. ,vol. 403, pp. 776- 781 ,(2000) , 10.1038/35001596
G Balla, H.S. Jacob, J Balla, M Rosenberg, K Nath, F Apple, J.W. Eaton, G.M. Vercellotti, Ferritin: a cytoprotective antioxidant strategem of endothelium. Journal of Biological Chemistry. ,vol. 267, pp. 18148- 18153 ,(1992) , 10.1016/S0021-9258(19)37165-0
Alexander Krause, Susanne Neitz, Hans-Jürgen Mägert, Axel Schulz, Wolf-Georg Forssmann, Peter Schulz-Knappe, Knut Adermann, LEAP‐1, a novel highly disulfide‐bonded human peptide, exhibits antimicrobial activity FEBS Letters. ,vol. 480, pp. 147- 150 ,(2000) , 10.1016/S0014-5793(00)01920-7
He Chang, Haruo Hanawa, Hui Liu, Tsuyoshi Yoshida, Manabu Hayashi, Ritsuo Watanabe, Satoru Abe, Ken Toba, Kaori Yoshida, Raafat Elnaggar, Shiro Minagawa, Yuji Okura, Kiminori Kato, Makoto Kodama, Hiroki Maruyama, Junichi Miyazaki, Yoshifusa Aizawa, Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats. Journal of Immunology. ,vol. 177, pp. 3635- 3643 ,(2006) , 10.4049/JIMMUNOL.177.6.3635
Elizabeta Nemeth, Gloria C. Preza, Chun-Ling Jung, Jerry Kaplan, Alan J. Waring, Tomas Ganz, The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study Blood. ,vol. 107, pp. 328- 333 ,(2005) , 10.1182/BLOOD-2005-05-2049
Elizabeta Nemeth, Marie S Tuttle, Julie Powelson, Michael B Vaughn, Adriana Donovan, Diane McVey Ward, Tomas Ganz, Jerry Kaplan, Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization Science. ,vol. 306, pp. 2090- 2093 ,(2004) , 10.1126/SCIENCE.1104742
Barry Halliwell, John M.C. Gutteridge, Biologically relevant metal ion-dependent hydroxyl radical generation. An update. FEBS Letters. ,vol. 307, pp. 108- 112 ,(1992) , 10.1016/0014-5793(92)80911-Y