Multiple Norovirus Infections in a Birth Cohort in a Peruvian Periurban Community

摘要: Background. Human noroviruses are among the most common enteropathogens globally, and a leading cause of infant diarrhea in developing countries. However, data measuring impact norovirus at community level sparse. Methods. We followed birth cohort children to estimate infection incidence Peruvian community. Stool samples from diarrheal episodes randomly selected nondiarrheal were tested by polymerase chain reaction for genogroup genotype. Excretion duration rotavirus coinfection evaluated subset episodes. Results. Two hundred twenty 189 1 2 years age, respectively. By year, 80% (95% confidence interval [CI], 75%–85%) experienced least years, 71% CI, 65%–77%) had episode norovirus-associated diarrhea. Genogroup II (GII) infections 3 times more frequent than (GI) infections. Eighteen genotypes found; GII genotype 4 accounted 41%. Median excretion was 34.5 days vs 8.5 GI (P = .0006). Repeat same common, but repeat rare. Mean length-for-age z score 12 months lower with prior compared uninfected (coefficient: −0.33 [95% −.65 −.01]; P .04); effect persisted 24 months. Conclusions. Norovirus occurs early life experience serial multiple genotypes, suggesting genotype-specific immunity. An effective vaccine would have substantial on morbidity, may need target genotypes.