Mechanisms of Chinese Red Yeast Rice Inhibition of Prostate Cancer Growth

摘要: Abstract : Prostate cancer is the second leading cause of deaths in men United States. Early prostate androgen-dependent, but later stages disease androgen-independent tumors arise with an eventual fatal outcome. Red Yeast Rice (RYR) a traditional food spice consumed throughout Asia and contains family monacolins, one which (monacolin K) identical to lovastatin, ability inhibit cholesterol synthesis. The objective study was determine whether RYR can growth androgen-dependent -independent xenograft underlying mechanisms. showed that inhibited both tumor volume by downregulation gene expression involved androgen synthesis (3beta-hydroxysteroid dehydrogenase type 2, aldo-keto reductase 1 member C3 steroid 5alpha 1) de novo synthesizing enzyme (3-hydroxy-3-methyl-glutaryl CoA reductase) its response element (sterol binding protein-2). also reduced receptor androgenindependent xenograft. Currently, profile as function diet examined microarray analysis. This would establish proof principle strengthen biological basis for human trials extract.