Metabolic Reprogramming in Cancer: Role of HPV 16 Variants.
作者： Napoleón Navarro-Tito , Miguel A. Mendoza-Catalán , Berenice Illades-Aguiar , Hilda Jiménez-Wences , Dinorah N. Martínez-Carrillo
DOI: 10.3390/PATHOGENS10030347
关键词: Warburg effect 、 Anaerobic glycolysis 、 Hypoxia-inducible factors 、 Cancer 、 Cancer cell 、 Cancer research 、 Oncogenicity 、 Retinoblastoma protein 、 Metabolic reprogramming 、 Biology
摘要: Metabolic reprogramming is considered one of the hallmarks in cancer and characterized by increased glycolysis lactate production, even presence oxygen, which leads cells to a process called “aerobic glycolysis” or “Warburg effect”. The E6 E7 oncoproteins human papillomavirus 16 (HPV 16) favor Warburg effect through their interaction with molecule that regulates cellular metabolism, such as p53, retinoblastoma protein (pRb), c-Myc, hypoxia inducible factor 1α (HIF-1α). Besides, impact variants HPV on metabolic proteins HIF-1α may be related oncogenicity favoring metabolism modifications satisfy energy demands necessary for viral persistence development. This review will discuss role contribution developing preserving malignant phenotype cancers associated infection.
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