SnO2 nanoparticles mediated nontraditional synthesis of biologically active 9-chloro-6,13-dihydro-7-phenyl-5H-indolo [3,2-c]-acridine derivatives
作者： Selvaraj Mohana Roopan , Fazlur Rahman Nawaz Khan , None
DOI: 10.1007/S00044-010-9381-7
关键词: Methylene 、 Stereochemistry 、 Nanoparticle 、 Biological activity 、 HeLa 、 Chemistry 、 Acridine derivatives 、 Cytotoxicity 、 Vero cell 、 Medicinal chemistry 、 In vitro
摘要: An efficient, practical, and eco-friendly method of preparation 9-chloro-6,13-dihydro-7-phenyl-5H-indolo[3,2-c]-acridines (3a–c) is reported by Friedlander condensation 2-amino-5-chlorobenzophenone 1 active methylene compound 3,4-dihydro-2H-carbazol-1(9H)-ones (2a–c) in the presence SnO2 nanoparticles under microwave irradiation. Indoloacridines, 3a–c, were screened for their vitro hemolytic activity, on human erythrocytes cytotoxicity, HeLa Vero cells.
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