Fluorescent and antioxidant studies of effectively synthesized isochromenopyrrolone analogues

摘要: An efficient strategy for the synthesis of 3-acetyl-2-methyl-1-phenylisochromeno [4,3-b] pyrrol-5(1H)-ones 4a–f have been developed using montmorillonite K10 as a catalyst. The reaction proceeded from acetyl acetone, substituted primary amines and ninhydrin via acidic media under solvent-free conditions. Compounds 4a–c exhibit green fluorescence UV light, their fluorescent properties in liquid state were investigated. All synthesized compounds subjected evaluation free radical scavenging activity. Among all tested 4a 4c exhibited good percentage inhibition comparison with standard, i.e. ascorbic acid.