Transient Estradiol Exposure during Middle Age in Ovariectomized Rats Exerts Lasting Effects on Cognitive Function and the Hippocampus

摘要: We determined whether transient exposure to estradiol during middle age in ovariectomized rats would exert lasting effects on cognition and the brain beyond period of exposure. Two experiments were conducted. Rats 10–11 months received vehicle control treatment throughout experiment, continuous or 40 d that ended 3 before behavioral training. In first trained a radial-maze working memory task killed 2 after termination estradiol. The hippocampus was immunostained for choline acetyltransferase estrogen receptors α (ERα) β (ERβ) by Western blotting. second experiment determine durability effects, behaviorally tested every other month until brains collected blotting 8 Maze testing included delay t...