Pedigree analysis of Hodgkin's disease in a Newfoundland genealogy.
作者： E. A. THOMPSON
DOI: 10.1111/J.1469-1809.1981.TB00339.X
关键词: Genetics 、 Allele frequency 、 Genealogy 、 Trait 、 Inheritance (genetic algorithm) 、 Immunodeficiency 、 Heterozygote advantage 、 Allele 、 Genetic linkage 、 Disease 、 Biology
摘要: An extensive Newfoundland genealogy shows a large number of cases lymphoreticular malignancies. A recessive pattern inheritance had been previously suggested, but no quantitative investigation the hypothesis was made. Here we have investigated variety aspects descent structure pedigree and shown that for only subset traits can inference be upheld. For Hodgkin's disease (HD) generalized immunodeficiency (ID) there is clear evidence HD/ID susceptibility allele. The remainder do not follow this pattern, show single-locus effect little any genetic effect. ancestry therefore in detail, likelihoods computed on pedigree. These confirmed nature trait, as also did risk analysis which quite clearly identified paths taken by determination these prerequisite linkage might further confirm trait.
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