Spectroscopic, thermal and antitumor investigations of sulfasalazine drug in situ complexation with alkaline earth metal ions.
作者： Moamen S. Refat , Soha F. Mohamed
DOI: 10.1016/J.SAA.2011.07.010
关键词: Alkali metal 、 Chemistry 、 Inorganic chemistry 、 Stoichiometry 、 Infrared spectroscopy 、 Thermal analysis 、 Ligand 、 Thermal decomposition 、 Mass spectrum 、 Metal
摘要: Abstract The complexes of sulfasalazine (H3Suz) with some alkaline metals Mg(II), Ca(II), Sr(II) and Ba(II) have been investigated. Sulfasalazine were synthesized characterized by spectroscopic tools; infrared spectra, electronic mass spectra. IR spectra the prepared suggested that H3Suz behaves as a bi-dentate ligand through carboxylic phenolic groups. molar conductance measurements gave an idea about non-electrolytic behavior complexes. thermal decomposition processes for metal(II) viz: [M(HSuz)(H2O)4] (where M = Mg(II), or Ba(II)) accomplished on basis TG/DTG DTA studies, formula conforms to stoichiometry based elemental analysis. kinetic analyses studied using Coats–Redfern Horowitz–Metzger equations. antitumor antimicrobial activities their evaluated.
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