Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells.
作者： Graeme Milligan
DOI: 10.1016/0167-4889(87)90176-5
关键词: Nucleotide 、 Transducin 、 Cholera toxin 、 ADP-ribosylation 、 Chemistry 、 Pertussis toxin 、 Molecular biology 、 Guanine 、 GTP' 、 Cholera 、 Biochemistry
摘要: Abstract Rat glioma C6 BU1 cells contain a pertussis toxin substrate of 40 kDa which does not appear to be identical with Gi,Go or transducin. The GTP analogue, GTP[γS], inhibited the rate toxin-catalysed ADPribosylation this protein, while GDP analogue GDP[βS] stimulated reaction. A protein same value was ADPribosylated by cholera in absence added guanine nucleotides. It is suggested that can for both and toxins under appropriate conditions.
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