Impact of regular physical activity on weekly warfarin dose requirement.

摘要: Warfarin is an oral anticoagulant agent with a narrow therapeutic index. There marked inter- and intra-patient variability in warfarin dose requirement. All factors influencing response are not known this study aims to evaluate if regular physical activity (RPA) determining factor. RPA level was collected the Stanford Brief Activity Survey 1064 incident users, as part of Quebec Cohort (QWC), Global Physical Questionnaire 618 patients from Montreal Heart Institute (MHI) Biobank. Linear regression performed model relationship after 3 months therapy QWC RPA, while controlling for height, weight, age, CYP2C9 (*2 *3 alleles) VKORC1 allele) genotype. prevalent users modeled MHI Biobank replication. A higher associated doses both cohorts. In QWC, could explain 5.4 % (P < 0.001) 0.9 % (P = 3.23 × 10−5) variance dose, univariate multivariable models, respectively. Similarly, found be 1.7 % (P = 0.0012) 0.5 % (P = 0.0391) inter-individual requirement before adjustment other covariables, The relevance clinical recommendations on maintain steady should assessed further studies. Electronic supplementary material The online version article (doi:10.1007/s11239-015-1248-9) contains material, which available authorized users.