Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.
作者： M R Klein , C A van Baalen , A M Holwerda , S R Kerkhof Garde , R J Bende
关键词: CD3 、 Viral load 、 Seroconversion 、 Virology 、 Cytotoxic T cell 、 CTL* 、 Asymptomatic 、 Viremia 、 Immunology 、 Biology 、 T cell
摘要: To gain more insight into the role of HIV-1-specific cytotoxic T lymphocytes (CTL) in pathogenesis AIDS, we investigated temporal relations between HIV-1 Gag-specific precursor CTL (CTLp), viral load, CD4+ cell counts, and function. Six HIV-1-infected subjects, who were asymptomatic for than 8 yr with counts > 500 cells/mm3, compared six subjects progressed to AIDS within 5 after seroconversion. In long-term asymptomatics, persistent responses very low numbers cells coincided normal stable preserved CD3 mAb-induced reactivity yr. five out rapid progressors CTLp also detected. However, early infection number circulating increased despite strong mounting responses. During subsequent clinical progression loss precipitating severe deterioration The possible relationships disease are discussed.
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Herman Waldmann, Ivan Lefkovits, Limiting Dilution Analysis of Cells in the Immune System ,(1979)
ZW Chen, LING Shen, MICHAEL D Miller, STEVEN H Ghim, AUSTIN L Hughes, NORMAN L Letvin, None, Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag. Journal of Immunology. ,vol. 149, pp. 4060- 4066 ,(1992)
A. Trocha, G. P. Mazzara, R. P. Johnson, B. D. Walker, T. M. Buchanan, Lin Yang, D. L. Panicali, HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells. Journal of Immunology. ,vol. 147, pp. 1512- 1521 ,(1991)
F Buseyne, M McChesney, F Porrot, S Kovarik, B Guy, Y Rivière, Gag-specific cytotoxic T lymphocytes from human immunodeficiency virus type 1-infected individuals: Gag epitopes are clustered in three regions of the p24gag protein. Journal of Virology. ,vol. 67, pp. 694- 702 ,(1993) , 10.1128/JVI.67.2.694-702.1993
J A Berzofsky, G M Shearer, M Clerici, H M Gebel, R N Boswell, R A Zajac, H Takahashi, D R Lucey, Detection of cytotoxic T lymphocytes specific for synthetic peptides of gp160 in HIV-seropositive individuals. Journal of Immunology. ,vol. 146, pp. 2214- 2219 ,(1991)
B Autran, F Michel, G Dadaglio, A Hoffenbach, C Mayaud, E Vilmer, F Plata, P Langlade-Demoyen, Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans. Journal of Immunology. ,vol. 142, pp. 452- 462 ,(1989)
M Baseler, G Pantaleo, H C Lane, S Koenig, A S Fauci, Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell population. Journal of Immunology. ,vol. 144, pp. 1696- 1704 ,(1990)
Leo W.G. Strijbosch, Wim A. Buurman, Ronald J.M.M. Does, Piet H. Zinken, Gerard Groenewegen, Limiting dilution assays Experimental design and statistical analysis Journal of Immunological Methods. ,vol. 97, pp. 133- 140 ,(1987) , 10.1016/0022-1759(87)90115-3
R A Koup, J T Safrit, Y Cao, C A Andrews, G McLeod, W Borkowsky, C Farthing, D D Ho, Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. Journal of Virology. ,vol. 68, pp. 4650- 4655 ,(1994) , 10.1128/JVI.68.7.4650-4655.1994
H Schuitemaker, M Koot, N A Kootstra, M W Dercksen, R E de Goede, R P van Steenwijk, J M Lange, J K Schattenkerk, F Miedema, M Tersmette, Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. Journal of Virology. ,vol. 66, pp. 1354- 1360 ,(1992) , 10.1128/JVI.66.3.1354-1360.1992