Treatment of acute radiodermatitis with an oil-in-water emulsion following radiation therapy for breast cancer: a controlled, randomized trial.

摘要: A side effect of radiotherapy for breast cancer is acute radiodermatitis. It a common practice to keep irradiated skin dry on account data from the 1950s that suggested this regimen limits dermatitis. However, severe dryness induced by irradiation results in itching and discomfort. Dry characterized scaliness, epidermal barrier dysfunction, reduced stratum corneum hydration, these signs symptoms are treatment with an emulsion. We performed randomized, controlled, open-label study 66 patients (ITT population), treating one group (n = 34) oil-in-water emulsion (WO1932), while leaving other untreated 32). Clinical scoring (ONS radiation reaction scoring, pruritus) biophysical measurements (stratum hydration transepidermal water loss (TEWL), as marker function) were determined at day 1 (directly after termination therapy), 8, 47 (± 7). Irradiation increased ONS score pruritus, whereas TEWL reduced. The primary hypothesis increase was significantly greater emulsion-treated compared early 8 days could not be confirmed. At end (day ± 7), however, normalization more advanced nearly reached values contralateral healthy skin. pruritus also revealed advantage group. did show significant changes during treatment. No adverse events caused regimens Treatment radiodermatitis well tolerated, enhanced improved clinical indicators, provided relief itching.