Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials

摘要: Radiation-induced skin reaction (RISR) is a common side effect that affects the majority of cancer patients receiving radiation treatment. RISR often characterised by swelling, redness, pigmentation, fibrosis, and ulceration, pain, warmth, burning, itching skin. The aim this systematic review was to assess effects interventions which prevent or manage in people with cancer. We searched following databases up November 2012: Cochrane Skin Group Specialised Register, CENTRAL (2012, Issue 11), MEDLINE (from 1946), EMBASE 1974), PsycINFO 1806), CINAHL 1981) LILACS 1982). Randomized controlled trials evaluating for preventing managing were included. primary outcomes development RISR, levels symptom severity. Secondary time taken develop erythema dry desquamation; quality life; heal, number severity measures; cost, participant satisfaction; ease use adverse effects. Where appropriate, we pooled results randomized using mean differences (MD) odd ratios (OR) 95% confidence intervals (CI). Forty-seven studies included review. These evaluated six types (oral systemic medications; care practices; steroidal topical therapies; non-steroidal dressings other). Findings from two meta-analyses demonstrated significant benefits oral Wobe-Mugos E (OR 0.13 (95% CI 0.05 0.38)) limiting maximal level (MD -0.92 -1.36 -0.48)). Another meta-analysis reported wearing deodorant does not influence 0.80 0.47 1.37)). Despite high area, there limited good, comparative research provides definitive suggesting effectiveness any single intervention reducing RISR. More required demonstrate usefulness wide range products are being used Future efforts should focus on promising interventions, such as zinc.