Vaccination with recombinant Parasite Surface Antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection.
作者： Anders Sjölander , Tracey M Baldwin , Joan M Curtis , Karin Lövgren Bengtsson , Emanuela Handman
DOI: 10.1016/S0264-410X(98)00075-9
关键词: Vaccination 、 Cellular immunity 、 Microbiology 、 Immune system 、 Virology 、 T lymphocyte 、 Immunogenicity 、 Leishmania major 、 Antigen 、 T cell mediated immunity 、 Biology
摘要: Vaccination with the native Parasite Surface Antigen 2 of Leishmania major Corynebacterium parvum as adjuvant protects mice from leishmaniasis through a Th1 mediated response. Here we show that vaccination recombinant form this protein, purified Escherichia coli and administered in iscoms or C. adjuvant, does not induce protective immunity despite induction responses. The results suggest depends on ability vaccinating antigen to Th1-like T cells be recalled by infection. Therefore, conformation antigens may play more role for cell than originally considered.
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sci-hub.se 参考文章(40)
K. Lovgren, B. Morein, The requirement of lipids for the formation of immunostimulating complexes (iscoms). Biotechnology and Applied Biochemistry. ,vol. 10, pp. 161- 172 ,(1988) , 10.1111/J.1470-8744.1988.TB00012.X
Emanuela Handman, Joan M. Curtis, Tracey M. Baldwin, Anders Sjölander, Induction of a Th1 Immune Response and Simultaneous Lack of Activation of a Th2 Response Are Required for Generation of Immunity to Leishmaniasis Journal of Immunology. ,vol. 160, pp. 3949- 3957 ,(1998)
P.J. Murray, T.W. Spithill, Variants of a Leishmania surface antigen derived from a multigenic family. Journal of Biological Chemistry. ,vol. 266, pp. 24477- 24484 ,(1991) , 10.1016/S0021-9258(18)54253-8
P J Murray, T W Spithill, E Handman, The PSA-2 glycoprotein complex of Leishmania major is a glycosylphosphatidylinositol-linked promastigote surface antigen. Journal of Immunology. ,vol. 143, pp. 4221- 4226 ,(1989)
Concepts in vaccine development. Walter de Gruyter. ,(1996) , 10.1515/9783110906660
J Champsi, D McMahon-Pratt, Membrane glycoprotein M-2 protects against Leishmania amazonensis infection. Infection and Immunity. ,vol. 56, pp. 3272- 3279 ,(1988) , 10.1128/IAI.56.12.3272-3279.1988
P C Melby, F J Andrade-Narvaez, B J Darnell, G Valencia-Pacheco, V V Tryon, A Palomo-Cetina, Increased expression of proinflammatory cytokines in chronic lesions of human cutaneous leishmaniasis. Infection and Immunity. ,vol. 62, pp. 837- 842 ,(1994) , 10.1128/IAI.62.3.837-842.1994
Heidi E. Drummer, David C. Jackson, Lorena E. Brown, Modulation of CD4+ T-cell recognition of influenza hemagglutinin by carbohydrate side chains located outside a T-cell determinant. Virology. ,vol. 192, pp. 282- 289 ,(1993) , 10.1006/VIRO.1993.1031
Richard M. Locksley, Jacques A. Louis, Immunology of leishmaniasis Current Opinion in Immunology. ,vol. 4, pp. 413- 418 ,(1992) , 10.1016/S0952-7915(06)80032-4
J. H. LeBowitz, C. M. Coburn, D. McMahon-Pratt, S. M. Beverley, Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 9736- 9740 ,(1990) , 10.1073/PNAS.87.24.9736