Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions.

摘要: Compelling data exist for programming of chronic later-life diseases and longevity by perinatal developmental challenges. Understanding mechanisms which life course health trajectory are set is fundamental to understanding aging. Appropriate approaches needed determine effects on cellular function. We have developed a baboon model in control mothers eat ad libitum while second group 70% the global diet fed controls, leading male female offspring intrauterine growth restriction (IUGR). shown that IUGR suffer from acceleration several age-related physiological declines. Here, we report skin-derived fibroblast with potential relevance mechanistic studies how impacts Fibroblasts were cultured skin biopsies taken adult baboons cohorts. IUGR-derived fibroblasts grew culture less well than controls those derived male, but not female, had significant reduction maximum respiration rate compared control-derived fibroblasts. also show relative levels mitochondrial protein subunits, including NDUFB8 cytochrome c oxidase subunit IV, reduced even after serial passaging culture. The lower electron transport system components provide accelerated aging setting programmed IUGR. This observation fits greater sensitivity males females many, all, outcomes response These will be powerful determination programming-aging interactions.