Development of tendon structure and function: regulation of collagen fibrillogenesis

摘要: In the tendon, development of mature mechanical properties is dependent on assembly a tendon-specific extracellular matrix. This matrix synthesized by tendon fibroblasts and composed collagen fibrils organized as fibers, well fibril-associated collagenous non-collagenous proteins. All these components are integrated, during growth, to form functional tissue. During development, fibrillogenesis progress through multiple steps where each step regulated independently, culminating in structurally functionally Collagen occurs series compartments fibril intermediates assembled grow process post-depositional fusion intermediates. Linear lateral growth after immature incorporated into fibers. The processes interactions macromolecules with fibrils. Interactions quantitatively minor fibrillar collagens, collagens proteoglycans influence different microdomains provide mechanism for regulate interactions.