Mouse Models in Tendon and Ligament Research

摘要: Mutant mouse models are valuable resources for the study of tendon and ligament biology. Many mutant used because their manifested phenotypes mimic clinical pathobiology several heritable disorders, such as Ehlers-Danlos Syndrome Osteogenesis Imperfecta. Moreover, these helpful discerning roles specific genes in development, maturation, repair musculoskeletal tissues. There categories with essential synthesis maintenance structures. The form function tissues depend highly upon fibril-forming collagens, primary extracellular macromolecules tendons ligaments. Models well regulatory molecules like FACITs SLRPs, important studying fibril assembly, growth, maturation. Additionally, growth factors transcription useful defining regulation cell proliferation, differentiation, cues that stimulate matrix synthesis. membrane-bound proteins assess cell-cell communication cell-matrix interaction. In some cases, special considerations need to be given spatio-temporal control a gene model. Thus, conditional inducible allow interest. Advances have provided tools gaining insight into