The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
作者： R. J. A. Bell , H. T. Rube , A. Kreig , A. Mancini , S. D. Fouse
关键词: Mutant 、 Telomerase reverse transcriptase 、 GA-Binding Protein Transcription Factor 、 Telomerase 、 Regulation of gene expression 、 Heterotetramer 、 Transcription factor 、 Molecular biology 、 Biology 、 Plasma protein binding
摘要: Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, which are fundamental steps in the …
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