Chikungunya virus and prospects for a vaccine

摘要: In 2004, chikungunya virus (CHIKV) re-emerged from East Africa to cause devastating epidemics of debilitating and often chronic arthralgia that have affected millions people in the Indian Ocean Basin Asia. More limited initiated by travelers subsequently occurred Italy France, as well human cases exported most regions world, including Americas where CHIKV could become endemic. Because circulates during an urban mosquito–human cycle, control transmission relies on mosquito abatement, which is rarely effective. Furthermore, there no antiviral treatment for infection licensed vaccine prevent disease. Here, we discuss challenges development a safe, effective affordable recent progress toward this goal.