Changes in Guinea pig cochlear hair cells after sound conditioning and noise exposure.
作者： Hongyan Zuo , Bo Cui , Xiaojun She , Mingquan Wu
DOI: 10.1539/JOH.L8032
关键词: Auditory brainstem response 、 Chemistry 、 Internal medicine 、 Stereocilia (inner ear) 、 Endocrinology 、 Anatomy 、 Hsp70 、 Noise-induced hearing loss 、 Guinea pig 、 Calcium in biology 、 Intracellular 、 Calmodulin
摘要: Sound conditioning has reduced noise-induced hearing loss in experimental mammalian animals and clinical observation. Forty guinea pigs were grouped as: A, control; B, noise exposure group; C, high level D, followed by a group. Auditory brainstem response thresholds measured. The cochlear sensory epithelia surface was observed microscopically. Calmodulin, F-actin heat shock protein 70 (HSP70) hair cells immunohistochemistrically stained. intracellular free calcium stained for confocal microscopy. ABR threshold shift after higher group C than showed quicker better recovery D C. Stereocilia the disarrangement of outer observed, with greatest changes seen groups B. most intensive immunohistochemical expressions calmodulin, F-actin, HSP70 found B A. highest intensity fluorescent Ca2+ staining isolated morphological studies confirmed protective effect from trauma sound conditioning. mechanism during enforced through increase cellular cytoskeleton proteins relieving overloading caused traumatic noise.
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