The effect of noise trauma following training exposures in the mouse.

摘要: The effect of moderate level acoustic stimulation, or 'training', on a subsequent high intensity noise exposure was studied in CBA/Ca mice. Eight groups mice were exposed to variety training paradigms as well different traumatic exposures. We sought combination which would result the maximum protective from trauma measured by auditory brainstem responses. Using narrow band centered at 4.5 kHz, we investigated effects 10-day 'interval' regimen, allowing rest period between successive exposures, several continuous These followed 24 h (also kHz) one three intensities, 107, 110, 117 dB SPL induce temporary, moderate, severe permanent threshold shift, respectively. In none these trained demonstrated any time up month following exposure. Several higher compound shifts after compared controls. After recovery 4 weeks nearly all tendency toward than control, untrained, animals. While no demonstrated, examination periods and exposures raised interesting questions for future investigation regarding inherent resistance induced mouse.