Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+channels

摘要: K+ channels containing Kv4.2 and Kv4.3 pore-forming subunits mediate most of the subthreshold-operating somatodendritic A-type current in CNS neurons. These are believed to be important regulating frequency repetitive firing, backpropagation action potential into dendrites, dendritic integration plasticity. Moreover, they have been implicated several diseases from pain epilepsy autism spectrum disorders. The lack toxins that specifically efficiently block these has hampered studies aimed at confirming their functional role involvement disease. AmmTX3 other related members α-KTX15 family scorpion shown cultured neurons, but specificity questioned because do not currents mediated by or expressed heterologous cells. Here we show high-affinity blockade depends on presence auxiliary DPP6 DPP10. proteins thought components Kv4 channel complex neurons for expression dendrites. validate use as a blocker Kv4-mediated