Unique Roles of SK and Kv4.2 Potassium Channels in Dendritic Integration

摘要: Abstract Focal activation of glutamate receptors in distal dendrites hippocampal pyramidal cells triggers voltage-dependent Ca 2+ channel-mediated plateau potentials that are confined to the stimulated dendrite. We examined role dendritic K + conductances determining amplitude, duration, and spatial compartmentalization potentials. Manipulations blocked SK-type -activated channels, including apamin BAPTA dialysis, increased duration without affecting their amplitude or compartmentalization. Kv4.2 A-type a dominant-negative construct 4-aminopyridine, by allowing them recruit neighboring dendrites. Prolongation block channels at branch points facilitated ability excitation trigger fast action SK thus underlie repolarization potentials, whereas confine these single branches, both act concert regulate synaptic integration.