Leptospirosis and immune-mediated hemolytic anemia: A lethal association.

摘要: Immune-mediated hemolytic anemia (IMHA) is a common cause of in dogs. The immune aggression towards erythrocytes can be triggered by many pathological conditions such as infection, inflammatory disease or neoplasia. Upon ruling out any eliciting conditions, diagnosis the primary immune-mediated made. In this particular case severe (tested positive for circulating antibodies against red blood cells with flow cytometry), vector-borne diseases (which are immunopathology Mediterranean countries) were excluded, leptospirosis was not. This resulted an unsuccessful immunosuppressive therapy prednisone, two whole transfusions and ultimately death patient. Leptospirosis (confirmed tests, micro-agglutination test PCR microbial DNA urine), mimic IMHA must considered its differential list causes. A liver involvement, that included elevated serum activity enzymes increased bile acid observed at admission suggested etiopathogenesis other than IMHA.