The Effect of Electrode Topography on the Magnetic Properties and MRI Application of Electrochemically-Deposited, Synthesized, Cobalt-Substituted Hydroxyapatite

作者: Wei-Chun Lin , Chun-Chao Chuang , Chen-Jung Chang , Ya-Hsu Chiu , Min Yan

DOI: 10.3390/NANO9020200

关键词: Cobalt oxideTitanium dioxideCobaltParticle sizeMRI contrast agentNanoparticleNanomaterialsMagnetic nanoparticlesChemical engineeringMaterials science

摘要: Magnetic nanoparticles are used to enhance the image contrast of magnetic resonance imaging (MRI). However, development with a low dose/high and non-toxicity is currently major challenge. In this study, cobalt-substituted hydroxyapatite deposited on titanium (Ti-CoHA) dioxide nanotubes (TNT-CoHA) were synthesized by electrochemical deposition method. The particle sizes Ti-CoHA TNT-CoHA 418.6 nm 127.5 nm, respectively, as observed using FE-SEM. It was shown that CoHA can be obtained smaller size nanotube (TNT) electrode plate. than Ti-CoHA. crystal internal cobalt oxide calculated an XRD pattern. results indicate in larger makes saturation magnetization (Ms) 12.6 times higher MRIs related properties particles. Therefore, has good at concentrations T₂ images. relaxivity coefficient for (340.3 mM-1s-1) (211.7 mM-1s-1), both commercial iron (103.0 mM-1s-1). We showed TNT substrate caused increase TNT-CoHA, thus effectively improving field strength MRI recognition. also rose Ms. Evaluation biocompatibility human osteosarcoma cells (MG63) indicated no toxic effects. On other hand, had excellent antibacterial effect, E. coli evaluation, effect powder powder. summary, electrochemically substrates considered potential candidate application agent. This paper comparative study how different plates affect (CoHA) nanomaterials.

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