Accumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitis
作者： Caliandra Pinto Araújo , Clarissa Araújo Silva Gurgel , Eduardo Antônio Gonçalves Ramos , Valéria Souza Freitas , Aryon Almeida Barbosa Júnior
DOI: 10.1007/S10735-010-9297-Z
关键词: Significant difference 、 Statistical difference 、 Mast cell tryptase 、 Epithelial dysplasia 、 Actinic cheilitis 、 Pathology 、 Dysplasia 、 Moderate Dysplasia 、 Immunohistochemistry 、 Chemistry
摘要: LCs and MCs are known to be directly influenced by UV radiation. This study investigated the presence of Langerhans cells (LCs) mast (MCs) in actinic cheilitis (AC) exhibiting epithelial dysplasia (ED). Using immunohistochemistry for CD1a cell tryptase, density was assessed 35 cases AC with different degrees ED. were found 32 whereas all cases. There an increase irrespective degree ED when compared normal lip mucosa (P = 0.04343). No statistical difference observed regarding > 0.05). Significant between mild moderate < significant correlation seen 0.1258). Although no could established ED; it is possible that accumulation plays immunostimulatory protective role defense against progression dysplasia. Further studies necessary determine development AC.
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