CD1a+ and CD83+ Langerhans cells are reduced in lower lip squamous cell carcinoma
作者： Juliane Oliveira Gomes , Marianne de Vasconcelos Carvalho , Felipe Paiva Fonseca , Rogério Oliveira Gondak , Márcio Ajudarte Lopes
DOI: 10.1111/JOP.12389
关键词:
摘要: Background Actinic cheilitis (AC) is a potentially malignant lesion diagnosed in the lip of patients chronically exposed to sun that may give rise fully invasive lower squamous cell carcinoma (LLSCC). It known ultraviolet radiation causes dendritic cells (DCs) depletion epidermis, but role this cellular population cancer progression remains uncertain. Therefore, study investigated distribution DCs normal, dysplastic and neoplastic tissues lip. Methods Thirteen cases mucocele, 42 ACs 21 LLSCC were retrieved original diagnoses confirmed by two oral pathologists, who further classified as low- high-risk lesions. Immunoreactions against CD1a CD83 identified immature mature DCs, respectively. Results Immature CD1a+ Langerhans (LCs) significantly decreased when compared morphologically normal (P 0.05), demonstrated concentration LCs than epithelium 0.05). Conclusion These results suggest epithelial LCs, not IDCs connective tissue, would represent an important step for development.
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Galina V. Shurin, M. R. Shurin, L. Pérez, B. Collins, I. L. Tourkova, D. Kogan, Comparative analysis of CD1a, S-100, CD83, and CD11c human dendritic cells in normal, premalignant, and malignant tissues Histology and Histopathology. ,vol. 20, pp. 1165- 1172 ,(2005) , 10.14670/HH-20.1165
M. Gutiérrez-Pascual, F.J. Vicente-Martín, J.G. Fernández-Álvarez, R. Martín-López, F. Pinedo-Moraleda, J.L. López-Estebaranz, Squamous cell carcinoma of the lip. A retrospective study of 146 patients. Journal of The European Academy of Dermatology and Venereology. ,vol. 26, pp. 1116- 1121 ,(2012) , 10.1111/J.1468-3083.2011.04227.X
Jashodeep Datta, Erik Berk, Jessica A. Cintolo, Shuwen Xu, Robert E. Roses, Brian J. Czerniecki, Rationale for a Multimodality Strategy to Enhance the Efficacy of Dendritic Cell-Based Cancer Immunotherapy. Frontiers in Immunology. ,vol. 6, pp. 271- 271 ,(2015) , 10.3389/FIMMU.2015.00271
S. Warnakulasuriya, J. Reibel, J. Bouquot, E. Dabelsteen, Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. Journal of Oral Pathology & Medicine. ,vol. 37, pp. 127- 133 ,(2008) , 10.1111/J.1600-0714.2007.00584.X
Caliandra Pinto Araújo, Clarissa Araújo Silva Gurgel, Eduardo Antônio Gonçalves Ramos, Valéria Souza Freitas, Aryon Almeida Barbosa Júnior, Luciana Maria Pedreira Ramalho, Jean Nunes dos Santos, Accumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitis Journal of Molecular Histology. ,vol. 41, pp. 357- 365 ,(2010) , 10.1007/S10735-010-9297-Z
O. Dumay, A. Karam, L. Vian, D. Moyal, C. Hourseau, P. Stoebner, J.L. Peyron, J. Meynadier, J.P. Cano, L. Meunier, Ultraviolet AI exposure of human skin results in Langerhans cell depletion and reduction of epidermal antigen-presenting cell function: partial protection by a broad-spectrum sunscreen. British Journal of Dermatology. ,vol. 144, pp. 1161- 1168 ,(2001) , 10.1046/J.1365-2133.2001.04225.X
Rogério O Gondak, Thais Mauad, Oslei P Almeida, Pablo A Vargas, Reduced number of CD1a+ and CD83+ interstitial dendritic cells in herpetic lesions (HSV-1+) of the tongue in patients with advanced-stage AIDS Histopathology. ,vol. 63, pp. 595- 598 ,(2013) , 10.1111/HIS.12196
Laetitia Furio, Odile Berthier-Vergnes, Blandine Ducarre, Daniel Schmitt, Josette Peguet-Navarro, UVA radiation impairs phenotypic and functional maturation of human dermal dendritic cells. Journal of Investigative Dermatology. ,vol. 125, pp. 1032- 1038 ,(2005) , 10.1111/J.0022-202X.2005.23904.X
Carla Ariotti, Vivian Petersen Wagner, Gabriela Salvadori, Vinicius Coelho Carrard, Marco Antônio Trevizani Martins, Joao Julio da Cunha Filho, Luise Meurer, Manoela Domingues Martins, VEGFR1 and VEGFR2 in lip carcinogenesis and its association with microvessel density Tumor Biology. ,vol. 36, pp. 7285- 7292 ,(2015) , 10.1007/S13277-015-3454-7
Mitsuhiko Iwamoto, Hisashi Shinohara, Akiko Miyamoto, Masaaki Okuzawa, Hideaki Mabuchi, Takehiro Nohara, Goki Gon, Masao Toyoda, Nobuhiko Tanigawa, Prognostic value of tumor-infiltrating dendritic cells expressing CD83 in human breast carcinomas International Journal of Cancer. ,vol. 104, pp. 92- 97 ,(2003) , 10.1002/IJC.10915