Treatments of actinic cheilitis: A systematic review of the literature

摘要: Background No large studies have defined the best treatment of actinic cheilitis. Methods We conducted a systematic review to define therapies for cheilitis in clinical response and recurrences. Results first identified 444 papers, 49 were finally considered, including 789 patients 843 treated areas. The following recorded order frequency: laser therapy, photodynamic therapy (PDT), 3% diclofenac 2.5% hyaluronic acid, PDT + 5% imiquimod, aminolevulinic acid–laser or methyl-aminolevulinic acid–laser, 5% fluorouracil, partial surgery, 0.015% ingenol mebutate, 50% trichloroacetic laser + PDT. Concerning primary outcome, complete was achieved 76.5% patients, 10.2% had Partial surgery showed highest rates (14 14 [100%] 244 260 [93.8%], respectively) with low Only limited number other therapies, exception PDT, 68.9% responses 12.6% Interestingly, when combined efficacy PDT significantly enhanced. Limitations Heterogeneity across studies. Conclusion Laser appears option among nonsurgical approaches cheilitis, higher sequentially imiquimod. Larger are needed confirm these data.