Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance
作者： Amanda J. Genders , Graham P. Holloway , David J. Bishop
DOI: 10.3390/IJMS21186948
关键词: Endocrinology 、 Mitochondrion 、 Respiratory function 、 Beta oxidation 、 Glucose uptake 、 Insulin resistance 、 Biology 、 Skeletal muscle 、 Type 2 diabetes 、 Carbohydrate metabolism 、 Internal medicine
摘要: As a major site of glucose uptake following meal, skeletal muscle has an important role in whole-body metabolism. Evidence humans and animal models insulin resistance type 2 diabetes suggests that alterations mitochondrial characteristics accompany the development resistance. However, it is unclear whether changes content, respiratory function, or substrate oxidation are central to occur response Thus, this review will aim evaluate apparent conflicting information placing mitochondria as key organelle muscle.
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