The Sentinel Lymph Node and Staging of Colorectal Cancer

摘要: The use of sentinel lymph node (SLN) biopsy (SLNB) for staging colorectal cancer (CRC) is a controversial issue. To clarify the usefulness this technique with its different modalities detection and various protocols histopathological work-up SLN, we performed meta-analysis (MA) about feasibility approach. We compared new method in to standard evaluation involvement. In our MA, global sensitivity mapping (SLNM) was 70% an 81% level specificity. pooled DAOR (Diagnostic Accuracy Odds Ratio) 10.7 (95% CI: 7–16.5). This means that patient whose SLN invaded has times more risk be node-positive than SLN-negative patient. CRC seems feasible but learning curve necessary. Saha et al. gained considerable experience technique, attested by their numerous publications. hands, had better (90%) other studies. SLNM should standardized future On hand, know SLNB successfully applied breast since it offers esthetical advantage avoiding large biopsy. regard, differs from cancer. Nevertheless, major benefit may obtained permits upstaging some involvement, thanks thin slicing SLN. Although issue still under debate, there growing evidence that, if at least RT-PCR-techniques were used, small tumour deposits might prognostic thus clinical value. Future studies focus on two aspects. First, careful selection allow determining whether improvement detect macrometastases feasible. Second, prospective trials using assessment compare Non-SLN incidence bear deposits. If proves sensitive predictive value evaluated.