Sentinel lymph node biopsy in colorectal cancer: a pilot study.

摘要: Background. Although sentinel lymph node biopsy technique is the gold standard in management of malignant melanoma and gradually replacing conventional axillary dissection breast cancer, its use colorectal cancer still controversial. The objective this study to demonstrate feasibility safety carcinoma. Methods. Consecutive patients with carcinoma without preoperative evidence nodal or distant metastatic disease were included. Intraoperative subserosal injection 1mL isosulfan blue (Lymphazurin ®) was performed around tumor cases colon ex-vivo infiltration used for rectal after resection completed. Blue stained nodes dissected submitted routine pathology exam. If deemed negative neoplasm, immunohistochemistry cytokeratin performed. specimen non-stained resected processed usual fashion. Sensitivity predictive value calculated adverse effects dye registered. Results. Ten included at least one identified each. Mean number non-sentinel 2.5 15.6 per patient, respectively. sensitivity both 100%. There no caused by dye. Conclusions. Sentinel feasible, has a high diagnostic accuracy harmless.